Dr. Charlotte Uetrecht

ZOOM Meeting

April 21st, 2021

4 pm

Chair: Dr. Gabrielle Vieyres



We are happy to announce that Dr. Charlotte Uetrecht (Heinrich Pette Institute, European XFEL GmbH, Hamburg) will present highlights of her research on SARS-CoV-2. We are looking forward to her talk in which she will provide insights into the dynamics of viral structures. Her talk is entitled "Flying viruses – from biophysical to structural characterisation". Also check out a recent article on her work: https://idw-online.de/de/news?print=1&id=764277 (only in German) and the latest publication on this topic: https://advances.sciencemag.org/content/7/10/eabf1004


Viruses affect basically all organisms on earth. Some are detrimental to human development, whereas those targeting pathogenic bacteria or crop pathogens can be beneficial for us. Structural mass spectrometry (MS) offers powerful tools to study viruses. Despite the remarkable sensitivity, the structural resolution is generally limited in MS. Therefore, we combine MS with various X-ray techniques and develop native MS equipment to enable visualizing transient states via single particle imaging at hard X-ray free-electron-lasers (XFELs). Coronaviruses built a complex replication machinery from non-structural proteins (nsps). These proteins are produced as long polyproteins and released by viral proteases resulting in a highly dynamic system. Latest results from native MS on various coronaviruses including SARS-CoV-2 will be presented highlighting polyprotein processing, protein complexation and drug screening.


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